George Plaster graduated from Battle  Ground Academy in 1977. He was inducted into the Distinguished Alumnus Hall of Fame in June 2008. He also graduated from Vanderbilt University in 1981.

Plaster is a Nashville native. His late father was a close friend of the late former Nashville Vols, Vanderbilt, and Georgia Bulldogs announcer Larry Munson. He is proud of his Greek-American heritage and makes frequent reference to it, being for a long time one of three Greek-Americans prominent in Nashville broadcasting.

In 2006, Plaster was named to the inaugural Talkers Magazine "Talkers 250" list, highlighting the 250 most influential talk radio hosts in America. He remained on the list in 2007 and 2008.

Plaster served as the color analyst, opposite Bob Jamison, for the Nashville Sounds baseball club in the 1980s, occasionally filing in on play-by-play. He was also the play-by-play voice for Memphis State for one season and Vanderbilt athletics for three seasons as well as the Nashville Kats Arena Football League franchise. Additionally, he did play-by-play on local television broadcasts of Georgia Tech football and Western Kentucky basketball games. In the mid-1990s, Plaster served as co-host of a television show entitled Sports Talk on WNAB-TV.

Plaster was featured on Mark Wills's 2003 single "And the Crowd Goes Wild", from his album of the same name.

Plaster accepted an offer from WNSR to host a show weekdays 2-4 PM effective September 3, 2019.[4] In the fall of 2021, this program was syndicated over several stations in the Middle Tennessee area, notably WKOM in Columbia, Tennessee, as the "Plaster Radio Network". In the summer of 2022, this program was moved to online streaming only under the auspices of Main Street Media.